| Product Name: |
NNMTi |
| Synonyms: |
5-amino-1-methylquinolin-1-ium iodide;5-amino-1MQ;NNMTi;5-Amino-1methylquinolinium iodide;5-Amino-1-methylquinolinium;NNMTi,inhibit,fusion,muSC,muscle stem cell,NNMT,Inhibitor,regenerative;NNMTi 5-amino-1MQ;1-methylquinolin-1-ium-5-amine iodide |
| CAS: |
42464-96-0 |
| NNMTi Chemical Properties |
| Melting point |
213-214 °C |
| storage temp. |
Store at -20°C |
| solubility |
Soluble in DMSO |
| Description |
NNMTi (CAS 42464-96-0) is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation. NNMT is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone. |
| Chemical Properties |
Brown to reddish brown solid. |
| Uses |
NNMTi is an enzyme overexpressed during skeletal muscle aging and is associated with the repair of damage to the NAD+ pathway, dysregulation of sirtuin1 activity, and increased senescence of muscle stem cells. |
Product Introduction
NNMTi is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) (IC50=1.2μM), which can selectively bind to NNMT substrate binding site residues. NNMTi can promote the differentiation of myoblasts in vitro and enhance the ability of fusion and regeneration of muscle stem cells in aged mice.
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