Product Description
Product Name: NNMTi (5-amino-1MQ)
Chemical Name: 5-amino-1-methylquinolin-1-ium iodide
CAS Number: 42464-96-0
Appearance: Red Powder
Purity: 99%
Product Description:
NNMTi (5-amino-1MQ) is a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), with an IC50 value of 1.2 μM. It binds selectively to substrate-binding site residues of NNMT. NNMTi has shown significant potential in promoting muscle cell differentiation in vitro and enhancing muscle stem cell fusion and regeneration in aged mice.
Applications:
-
Muscle Regeneration Research:
- Enhances the differentiation of C2C12 myoblasts and supports muscle regeneration after injury.
- Increases the proliferation and activation of muscle stem cells (muSCs).
-
Cell Biology and Aging Studies:
- Useful for studying NNMT's role in aging-related muscle degeneration and cellular differentiation.
Mechanism of Action:
NNMTi inhibits nicotinamide N-methyltransferase activity, promoting differentiation and fusion of myoblasts while enhancing the regenerative ability of aged muscle stem cells.
In Vitro Studies:
- Myoblast Differentiation:
- NNMTi (10-30 μM; 96 hours) induces a concentration-dependent increase in differentiation of C2C12 myoblasts.
- At 30 μM, NNMTi leads to 18% MHC-positive myotube nuclei, representing a 45% increase compared to untreated cells.
In Vivo Studies:
- Muscle Regeneration in Mice:
- Subcutaneous injection of NNMTi (5 mg/kg and 10 mg/kg for 2 weeks) significantly improves muscle regeneration post-injury.
- Results in 60% and 75% higher incidence of proliferating/active muscle stem cells (muSCs) at 5 mg/kg and 10 mg/kg, respectively.
- The number of fibers with EdU+ myonuclei increases by 40% and 48% at the respective doses.
- No systemic toxicity was observed even after daily dosing for 1 week, with normal levels of glucose, cholesterol, plasma proteins, and electrolytes.
Key Features:
- Selective Inhibition: High specificity for NNMT with minimal off-target effects.
- Muscle Differentiation: Promotes myoblast fusion and differentiation effectively.
- Safe Profile: Well-tolerated in vivo with no systemic toxicity.
Storage Information:
- Store at -20°C in a sealed, dry container. Protect from moisture and light to maintain stability.
Use Cases:
- Regenerative Medicine: Investigating therapies for muscle regeneration and aging-related muscle disorders.
- Cell Signaling Studies: Exploring NNMT's role in cellular differentiation and metabolism.
This product is for research purposes only and not for human or veterinary use. For additional details or bulk inquiries, please contact us.
| Product name |
Tize
Retatrutid
Cagrilintid
Matdutid
Survotid
Mots - c |
| Purity |
99.7% above |
| Janoshik test |
avaiable |
| Storage |
Please Storage in The Fridge After Receiving |
| Specification |
5mg,10mg, 15mg, 20mg, 30mg |
| Color |
White lyophilized powder |
| Stock |
in stock |
| packing |
Vacuum sealing |
| Shipping |
FedEx, DHL, EMS, TNT, Royal Mail, Postnl |
Contact APP:
WA:+86,133,1599,6897
Product name:
|
Specifications: |
| Tize |
2mg, 5mg, 10mg |
| Retatrutid |
2mg, 5mg, 10mg |
| Cagrilintid |
2mg, 5mg, 10mg |
| Tize/Cagri |
2.5mg+2.5mg |
| cagrilintide Blend product |
2.4mg+2.4mg or 2.5mg+2.5mg |
| Melanot2 |
10mg |
| Sema x |
2mg, 5mg, 10mg |
| Selan k |
2mg, 5mg, 10mg |
| Dsi p |
2mg, 5mg, 10mg |
| S.nap-8 |
10mg |
| AO.D |
2mg, 5mg, 10mg |
| Pinealon |
10mg |
| Nad+ |
500mg, 750mg, 1000mg |
Please feel free to contact "Helen" for price list! |
Shipping Advise:
1. By Express Suitable for under 50kg, Fast:3-7 days.
Door to door service. Easy to pick up the goods.
2. By Air Suitable for more than 50 kg, Fast:3-7 days,
Airport to airport. professional broker needed.
3. By sea Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
Service:
1. Any inquiries will be replied within 24 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.
Advantage:
1. Faster delivery: Sample order in stock and 3-7 days for bulk production.
2. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
1.Will you supply samples for test the quality?
Yes,the shipping cost is borne by customers.
2.What is the payment term?
T/T, WU,Moneygram, B.T.C, L/C and so on.
3.What is your package?
Powder:Aluminium foil bag
Liquid: Plastic bottle/Drum
Bulk order: Fiber drum or steel drum.
4.What is your delivery term and delivery period?
FOB, CIF, etc.
Delivery time around 5-12 days
5.How to delivery by express?
A: Tracking number available within 3 working days after payment.Usually use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
8.How to make orders?
A: Send inquiry to us,we do the offer. Then we will arrange shipping. After delivery we will offer tracking No...
Audited Supplier 
){kind=link}